the effect of metyrosine/prednisolone combination to oophorectomy-induced osteoporosis

background:   objective: it was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine.   materials and methods: bone mineral density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (alp) measurements were performed. obtained results were compared with that of alendronate. results: oophorectomy induced osteoporosis was exacerbated by methylprednisolone. alentronate prevented ovariectomised induced osteoporosis, but it couldn’t prevent methylprednisolone +ovariectomised induced osteoporosis in rats. conclusion: combined treatment with methylprednisolon and metyrosine was the best treatment for preventing osteoporosis but metyrosine alone couldn’t prevent osteoporosis in ovariectomised rats.